The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …

The advent of high-throughput single-cell genomics technologies has fundamentally
transformed biological sciences. Currently, millions of cells from complex biological tissues …

The ability to interrogate single cells in vivo continues to yield new insights into the birth of
the first essential organ system of the developing embryo. A comparison of the regulation of …

Biomedical research relies heavily on the use of model organisms to gain insight into human
health and development. Traditionally, the mouse has been the favored vertebrate model …

Recent advances in organoid and genome editing technologies are allowing for
perturbation experiments at an unprecedented scale. However, before doing such …

Single-cell transcriptomics has revealed conserved and divergent programmes of
organogenesis in mammals, but existing studies have focused on eutherians. Marsupials …

Perturbation studies using gene knockouts have become a key tool for understanding the
roles of regulatory genes in development and disease. Here we systematically characterise …

Red blood cells (RBCs) comprise a critical component of the cardiovascular network, which
constitutes the first functional organ system of the developing mammalian embryo …

Adult blood cells are produced in the bone marrow by hematopoietic stem cells (HSCs), the
origin of which can be traced back to fetal developmental stages. Indeed, during mouse …