Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
Selective and precise activation of signaling transduction cascades is key for cellular
reprogramming and tissue regeneration. However, the development of small-or large …
reprogramming and tissue regeneration. However, the development of small-or large …
[HTML][HTML] Potency Assays for Mesenchymal Stromal Cell Secretome-Based Products for Tissue Regeneration
G Sagaradze, A Monakova, A Efimenko - International Journal of …, 2023 - mdpi.com
Adult stem cells maintaining tissue homeostasis and regeneration are tightly regulated by
their specific microenvironments or stem cell niches. The dysfunction of niche components …
their specific microenvironments or stem cell niches. The dysfunction of niche components …
[HTML][HTML] Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
W Liao, X Chen, S Zhang, J Chen, C Liu, K Yu… - Cell Communication and …, 2024 - Springer
Background Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery
from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is …
from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is …
RSPO3 抑制体内结直肠癌移植瘤生长和增加NK 细胞浸润的作用研究
周聪， 何丽娜， 成小姣， 黄廷磊， 涂水平 - 中国癌症杂志, 2023 - china-oncology.com
背景与目的: 结直肠癌的发生, 发展涉及多个癌基因的激活和抑癌基因的失活, 野生型R-
脊椎蛋白3 (R-spondin 3, RSPO3) 在结直肠癌生长中的作用目前尚不清楚, 本研究旨在探讨 …
脊椎蛋白3 (R-spondin 3, RSPO3) 在结直肠癌生长中的作用目前尚不清楚, 本研究旨在探讨 …
Effect of RSPO3 on inhibiting the growth of colorectal cancer transplanted tumors and increasing NK cell infiltration in vivo
Z Cong, HE Lina, C Xiaojiao, H Tinglei… - China …, 2023 - china-oncology.com
Background and purpose: The occurrence and development of colorectal cancer involve the
activation of multiple oncogenes and the inactivation of tumor suppressor genes. At present …
activation of multiple oncogenes and the inactivation of tumor suppressor genes. At present …