Oral carcinogenesis is a multistep process characterized by a summation of multiple genetic
and epigenetic alterations in key regulatory genes. The silencing of genes by aberrant …

Cancer metastasis presents a significant clinical challenge due to its impact on patient
survival rates. Early detection of metastasis is pivotal for effective intervention and improved …

Introduction The diagnosis of hepatocellular carcinoma (HCC) is made at a relatively
advanced stage resulting in poor prognosis. Alpha-fetoprotein and liver ultrasound have …

Toward the discovery of novel reliable biomarkers, epigenetic alterations have been
repeatedly proposed for the diagnosis and the development of therapeutic strategies against …

Background Liquid biopsy has emerged as a promising, non-invasive diagnostic approach
in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise …

The advances in scientific knowledge on biological therapies of the last two decades have
impressively oriented the clinical management of non-small-cell lung cancer (NSCLC) …

Whole-genome bisulfite sequencing (BS-Seq) measures cytosine methylation changes at
single-base resolution and can be used to profile cell-free DNA (cfDNA). In plasma …

Background Detecting organ and tissue damage is essential for early diagnosis, treatment
decisions, and monitoring disease progression. Methylation-based assays offer a promising …

DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …