Although resistance to poly (ADP‐ribose) polymerase inhibitors (PARPi) has gradually
become a major challenge in the maintenance therapy for high‐grade serous ovarian …

Since colon cancer has a high rate of shedding of tumour fragments into the blood, several
research efforts are now focused on the investigation of the minimal residual disease …

For patients with stage I/IIA non–small-cell lung cancer (NSCLC), surgical resection is the
standard treatment. However, some of these patients are not candidates for surgery or …

Multiple myeloma (MM) is an incurable hematological cancer with high spatial-and temporal-
heterogeneity. Invasive single-point bone marrow sampling cannot capture the tumor …

Prostate cancer is one of the most common malignancies in men. Over time, it can
metastasize and become lethal once it exhausts hormonal therapies and transitions into …

In clinical oncology, cell-free DNA (cfDNA) has shown immense potential in its ability to
noninvasively detect cancer at various stages and monitor the progression of therapy …

Background The accuracy of blood-based early tumour recognition is compromised by
signal production at non-tumoral sites, low amount of signal produced by small tumours, and …

Aim: Noninvasive biomarkers such as methylated ccfDNA from plasma could help to support
the diagnosis of Alzheimer's disease (AD). Methods: A targeted sequencing protocol was …

A number types of extracellular DNA (eg, cell-free, cfDNA) circulate in human blood,
including mitochondrial, transcriptome, and regulatory DNA, usually at low concentrations …

Due to its decade‐long progression, colorectal cancer (CRC) is most suitable for population
screening to achieve a significant reduction in its incidence and mortality. DNA methylation …