The incidence of aortic valve stenosis (AS), the most common reason for aortic valve
replacement (AVR), increases with population ageing. While untreated AS is associated with …

Heart failure is an important, and growing, cause of morbidity and mortality. Half of patients
with heart failure have preserved ejection fraction, for whom therapeutic options are limited …

The ubiquitous second messenger 3′, 5′-cyclic adenosine monophosphate (cAMP)
regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular …

Key points Optogenetics‐based defibrillation, a theoretical alternative to electrotherapy,
involves expression of light‐sensitive ion channels in the heart (via gene or cell therapy) and …

Human dilated cardiomyopathy (DCM) manifests as a profound reduction in biventricular
cardiac function that typically progresses to death or cardiac transplantation. There is no …

Introduction: Reduced synchrony of calcium release and t-tubule structure organization in
individual cardiomyocytes has been linked to loss of contractile strength and arrhythmia …

Membrane tubulation coupled with fission (MTCF) is a widespread phenomenon but
mechanisms for their coordination remain unclear, partly because of the lack of assays to …

Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the
heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B …

Background: NEXN (nexilin) is a protein of the junctional membrane complex required for
development of cardiac T-tubules. Global and cardiomyocyte-specific loss of Nexn in mice …

Background Heart failure is a common secondary complication following a myocardial
infarction (MI), characterized by impaired cardiac contraction and t‐tubule (t‐t) loss …