Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently
identified as a general heart failure (HF) hallmark. However, whether TT per se or the overall …

We present a novel framework, Opto-SICM, for studies of cellular interactions in live cells
with high spatiotemporal resolution. The approach combines scanning ion conductance …

Contacts between the endoplasmic reticulum (ER) and plasma membrane (PM) contain
specialized tethering proteins that bind both ER and PM membranes. In excitable cells, ER …

The ability to differentiate induced-pluripotent stem cells into cardiomyocytes (iPSC-CMs)
has opened up novel avenues for potential cardiac therapies. However, iPSC-CMs exhibit a …

Beating cardiomyocytes undergo fast morphodynamics during the contraction–relaxation
cycle. However, imaging these morphodynamics with a high spatial and temporal resolution …

Mammalian ventricular myocytes are characterised by the presence of an extensive
transverse (t-) tubule network which is responsible for the synchronous rise of intracellular …

Transverse tubules (T-tubules) are orderly invaginations of the sarcolemma in mammalian
cardiomyocytes. The integrity of T-tubule architecture is critical for cardiac excitation …

The cell membrane capacitance (Cm) and characteristic frequencies (fc) of tissues can be
obtained using segmental bioelectrical impedance spectroscopy (S-BIS). Higher Cm and …

Cardiac transverse (t)‐tubules are altered during disease and may be regulated by stretch‐
sensitive molecules. The relationship between variations in the degree and duration of load …

Insulin was discovered over 100 years ago. Whilst the first half century defined many of the
physiological effects of insulin, the second emphasised the mechanisms by which it elicits …