Although cancer and aging have been studied as independent diseases, mounting
evidence suggests that cancer is an aging-associated disease and that cancer and aging …

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of
continuous investigation because of the pandemic's extensive demographic impact and long …

Telomeres are repetitive DNA sequences at the ends of eukaryote chromosomes. Telomere
loss limits the number of times cells can divide and is intimately involved in cell loss and …

The klotho gene was identified as an “aging-suppressor” gene in mice that accelerates
aging when disrupted and extends life span when overexpressed. It encodes a single-pass …

Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms …

Use of model organisms in aging research is problematic because our ability to extrapolate
across the tree of life is not clear. On one hand, there are conserved pathways that regulate …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of
individuals aged over 60 years. While rodents are widely-used model organisms, which …

Stress exposure can leave long-term footprints within the organism, like in telomeres (TLs),
protective chromosome caps that shorten during cell replication and following exposure to …