Decoding tumor heterogeneity in uveal melanoma: basement membrane genes as novel biomarkers and therapeutic targets revealed by multi-omics approaches for …

Y Li, H Cai, J Yang, X Xie, S Pei, Y Wu… - Frontiers in …, 2023 - frontiersin.org
Background: Uveal melanoma (UVM) is a primary intraocular malignancy that poses a
significant threat to patients' visual function and life. The basement membrane (BM) is critical …

A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

X Bao, Q Li, D Chen, X Dai, C Liu, W Tian, H Zhang… - Cell Reports …, 2024 - cell.com
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components.
The CRC tumor microenvironment (TME) has been characterized well at single-cell …

The predictive efficacy of programmed cell death in immunotherapy of melanoma: A comprehensive analysis of gene expression data for programmed cell death …

C Yue, W Lian, M Duan, D Xia, X Cao… - Environmental …, 2024 - Wiley Online Library
In this study, genes linked to prognosis in skin cutaneous melanoma (SKCM) involved in
programmed cell death (PCD) were identified and confirmed and prognostic models based …

[HTML][HTML] Machine learning–based diagnostic evaluation of shear-wave elastography in BI-RADS category 4 breast cancer screening: a multicenter, retrospective study

Y Tang, M Liang, L Tao, M Deng, T Li - Quantitative Imaging in …, 2022 - ncbi.nlm.nih.gov
Background Ultrasound is commonly used in breast cancer screening but lacks
quantification ability and diagnostic power due to its low specificity, which can lead to …

Potential of testis-derived circular RNAs in seminal plasma to predict the outcome of microdissection testicular sperm extraction in patients with idiopathic non …

C Ji, Y Wang, X Wei, X Zhang, R Cong… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do testis-derived circular RNAs (circRNAs) in seminal plasma have
potential as biomarkers to predict the outcome of microdissection testicular sperm extraction …

Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia

X Wang, S Wu, L Sun, P Jin, J Zhang, W Liu, Z Zhan… - Scientific Reports, 2023 - nature.com
The non-receptor protein tyrosine phosphatases gene family (PTPNs) is involved in the
tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid …

Identification of FXYD6 as the novel biomarker for glioma based on differential expression and DNA methylation

W Hou, J Cai, P Shen, S Zhang, S Xiao, P You… - Cancer …, 2023 - Wiley Online Library
Objective As a single‐transmembrane protein of the FXYD family, FXYD6 plays different
roles under physiological and pathological status, especially in the nervous system. This …

Accurate, non-destructive, and high-throughput age estimation for Golden perch (Macquaria ambigua spp.) using DNA methylation

B Mayne, T Espinoza, DA Crook, C Anderson… - Scientific Reports, 2023 - nature.com
Age structure information of animal populations is fundamental to their conservation and
management. In fisheries, age is routinely obtained by counting daily or annual increments …

Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma

C Li, X Cui, Y Li, D Guo, S He - Scientific Reports, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. Currently, overcoming the drug resistance in HCC is a critical challenge and …

A novel prognostic model for cutaneous melanoma based on an immune-related gene signature and clinical variables

Y Tang, H Feng, L Zhang, C Qu, J Li, X Deng… - Scientific Reports, 2022 - nature.com
Abundant evidence has indicated that the prognosis of cutaneous melanoma (CM) patients
is highly complicated by the tumour immune microenvironment. We retrieved the clinical …