Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments

ZM Liu, MH Yang, K Yu, ZX Lian… - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects
humans and animals which make coronavirus disease 2019 (COVID-19) a grievous …

Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads

PJ Baker, EP Amaral, E Castro, AC Bohrer… - Frontiers in …, 2023 - frontiersin.org
Viral co-infections have been implicated in worsening tuberculosis (TB) and during the
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …

COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

BCG mediated protection of the lung against experimental SARS-CoV-2 infection

KL Hilligan, S Namasivayam, A Sher - Frontiers in Immunology, 2023 - frontiersin.org
The observation of reduced COVID-19 incidence and severity in populations receiving
neonatal intradermal BCG vaccination vaccine raised the question of whether BCG can …

Serum of COVID-19 patients changes neuroinflammation and mitochondrial homeostasis markers in hippocampus of aged rats

YHA Montenegro, LD Bobermin, P Sesterheim… - Journal of …, 2023 - Springer
Patients affected by COVID-19 present mostly with respiratory symptoms but acute
neurological symptoms are also commonly observed. Furthermore, a considerable number …

Induction of Superior Systemic and Mucosal Protective Immunity to SARS-CoV-2 by Nasal Administration of a VSV–ΔG–Spike Vaccine

Y Yahalom-Ronen, S Melamed, B Politi, N Erez… - Vaccines, 2024 - mdpi.com
The emergence of rapidly spreading variants of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) poses a major challenge to vaccines' protective efficacy …

Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses

M Rodríguez-Pulido, E Calvo-Pinilla, M Polo… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a
potentially severe respiratory disease, the coronavirus disease 2019 (COVID-19), an …

Herbo-mineral formulation, Divya-Swasari-Vati averts SARS-CoV-2 pseudovirus entry into human alveolar epithelial cells by interfering with spike protein-ACE 2 …

A Balkrishna, S Goswami, H Singh, V Gohel… - Frontiers in …, 2022 - frontiersin.org
The herbo-mineral formulation, Divya-Swasari-Vati (DSV), is a well-known Ayurvedic
medication for respiratory ailments. In a recent pre-clinical study, DSV rescued humanized …