SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …

The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

Rationale: Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers
great opportunities for cardiac disease modeling and cardiac regeneration. A major …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and …

Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer
(PCa) growth. However, how FOXA1 levels are regulated remains elusive and its …

Methylated lysine and arginine residues in histones represent a crucial part of the histone
code, and recognition of these methylated residues by protein interaction domains …