Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2
B Dale, C Anderson, KS Park… - ACS Pharmacology & …, 2022 - ACS Publications
Enhancer of zeste homolog 2 (EZH2), a catalytic subunit of polycomb repressive complex 2
(PRC2), is overexpressed in triple-negative breast cancer (TNBC), correlating with poor …
(PRC2), is overexpressed in triple-negative breast cancer (TNBC), correlating with poor …
The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
M Gunawan, N Venkatesan, JT Loh, JF Wong… - Nature …, 2015 - nature.com
A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation
has been suggested, but the molecular mechanisms underpinning this extranuclear function …
has been suggested, but the molecular mechanisms underpinning this extranuclear function …
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
How stage-specific enhancer dynamics modulate gene expression patterns essential for
organ development, homeostasis and disease is not well understood. Here, we addressed …
organ development, homeostasis and disease is not well understood. Here, we addressed …
The promise for histone methyltransferase inhibitors for epigenetic therapy in clinical oncology: a narrative review
Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …
specific gene expression in mammals. Changes in gene expression and malignant cellular …
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering
developmental transcriptional programs. Here we use biotinylated knockin alleles of seven …
developmental transcriptional programs. Here we use biotinylated knockin alleles of seven …
[HTML][HTML] Diverse involvement of EZH2 in cancer epigenetics
P Völkel, B Dupret, X Le Bourhis… - American journal of …, 2015 - ncbi.nlm.nih.gov
EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …
Epigenetic regulation in cancer progression
Cancer is a disease arising from both genetic and epigenetic modifications of DNA that
contribute to changes in gene expression in the cell. Genetic modifications include loss or …
contribute to changes in gene expression in the cell. Genetic modifications include loss or …
No easy way out for EZH2: its pleiotropic, noncanonical effects on gene regulation and cellular function
Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes
including organ development and homeostasis, epigenomic and transcriptomic regulation …
including organ development and homeostasis, epigenomic and transcriptomic regulation …
Emerging roles of lysine methylation on non-histone proteins
Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …
important for the epigenetic regulation of transcription and chromatin in eukaryotes …
Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity
Fibrosis is recognized as the major pathological change in adipose tissue during the
development of obesity. However, the detailed mechanisms governing the interactions …
development of obesity. However, the detailed mechanisms governing the interactions …