The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the
developmental processes of proliferation and cellular identity establishment are carried out …

Polycomb-group (PcG) complexes are multiprotein, evolutionarily conserved epigenetic
machineries that regulate stem cell fate decisions and development, and are also implicated …

Background: DNA methylation acts as a mechanism of gene transcription regulation. It has
recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart …

The first genes composing the Polycomb group (PcG) were identified 50 years ago in
Drosophila melanogaster as essential developmental functions that regulate the correct …

Protein lysine methylation is a critical and dynamic post-translational modification that can
regulate protein stability and function. This post-translational modification is regulated by …

Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …

Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …

Background Tumor metastasis is responsible for 90% of cancer-related deaths. Recently, a
strong link between microRNA dysregulation and human cancers has been established …

Polycomb protein histone methyltransferase, enhancer of Zeste homolog 2 (EZH2), is
frequently overexpressed in human malignancy and is implicated in cancer cell proliferation …

Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same
enzymes that also modify histones, with important functional consequences. We have …