Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells.
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex …

Purpose: Deregulation or mutation of the EZH2 gene causes various tumors, including clear
cell renal cell carcinoma (ccRCC). Although several splice variants of EZH2 have been …

Epigenetic modifications in cancer stem cells largely result in phenotypic and functional
heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste …

Protein methylation is a key post-translational modification whose effects on gene
expression have been intensively studied over the last two decades. Recently, renewed …

Epigenetic modifications regulate critical biological processes that play a pivotal role in the
pathogenesis of cancer. Enhancer of Zeste Homolog 2 (EZH2), a subunit of the Polycomb …

Abstract Long noncoding RNA (LncRNA) PVT1 has recently been reported to be involved in
the development of hepatocellular carcinoma (HCC). We aimed to elucidate the correlation …

Polycomb group proteins are important epigenetic regulators for cell proliferation and
differentiation, organ development, as well as initiation and progression of lethal diseases …

Transcription factors regulate formation and function of the heart, and perturbation of
transcription factor expression and regulation disrupts normal heart structure and function …

The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential
cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell …

Transcriptional regulation of thousands of genes instructs complex morphogenetic and
molecular events for heart development. Cardiac transcription factors choreograph gene …