It is widely accepted that epigenetic alterations are associated with different stages of tumour
formation and progression in many cancers. Therefore, epigenetic abnormalities in cancers …

The ability to convert human somatic cells efficiently to neurons facilitates the utility of patient-
derived neurons for studying neurological disorders. As such, ectopic expression of …

Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Most
mechanistic studies focus on their canonical functions, while therapeutic approaches target …

The embryonic vertebrate heart tube develops an atrioventricular canal that divides the atrial
and ventricular chambers, forms atrioventricular conduction tissue and organizes valve …

Abstract Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone‐H3 (H3K27me3)
as part of the polycomb repressive complex 2 (PRC 2) together with Suz12 and Eed …

Enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2
(PRC2), is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine …

Cancer has become a prominent cause of death, accounting for approximately 10 million
deaths worldwide as per the World Health Organization report 2020. Epigenetics deal with …

Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor
genes remain to be systemically identified for lung cancer. Through the genome-wide …

The intestinal epithelium performs vital roles in organ function by absorbing nutrients and
providing a protective barrier. The zinc-finger containing transcription factors GATA4 and …

Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery
directed at histone epigenetic modulators has gained impressive advances with six drugs …