Neural crest cells arise from the border of the neural plate and epidermal ectoderm, migrate
extensively and differentiate into diverse cell types during vertebrate embryogenesis …

Wnt/β-catenin signaling is required for embryonic stem cell (ESC) pluripotency by inducing
mesodermal differentiation and inhibiting neuronal differentiation; however, how β-catenin …

Understanding the mechanisms that regulate cell type-specific transcriptional programs
requires developing a lexicon of their genomic regulatory elements. We developed a …

Differentiation and activation of T cells require the activity of numerous histone lysine
methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent …

Background & Aims Patterning of the small intestinal epithelium along its cephalocaudal
axis establishes three functionally distinct regions: duodenum, jejunum, and ileum. Efficient …

Background & Aims The embryonic small intestinal epithelium is highly proliferative, and
although much is known about mechanisms regulating proliferation in the adult intestine, the …

Cancer stem-like cells (CSCs) is a cell population in glioma with capacity of self-renewal
and is critical in glioma tumorigenesis. Parallels between CSCs and normal stem cells …

Proper determination of cell fates depends on epigenetic information that is used to preserve
memory of decisions made earlier in development. Post-translational modification of histone …

Altered epidermal differentiation characterizes numerous skin diseases affecting> 25% of
the human population. Here we identified Fra-2/AP-1 as a key regulator of terminal …

Epigenetic regulation is critical for the precise control of cellular fate and developmental
programs. Disruption of epigenetic information is increasingly appreciated as a potential …