Introduction Most breast cancer-related deaths arise from triple-negative breast cancer
(TNBC). Molecular heterogeneity, aggressiveness and the lack of effective therapies are …

Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic
implants induce inflammation, leading to chronic pain and impaired fertility. Characterized …

Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

Despite the remarkable advances in the diagnosis and treatment of breast cancer patients,
the presence or development of metastasis remains an incurable condition. Bone is one of …

Introduction Breast cancer (BC) is the most common cancer in women and, despite the
undeniable improvements in the outcome of these patients obtained in the last decade, the …

Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …

Triple-negative breast cancers (TNBC) comprise biologically and clinically heterogeneous
diseases characterized by the lack of hormone receptors (HR) and HER2 expression. This …

Introduction In light of the clinically meaningful results of the PI3K inhibitors in PIK3CA-
mutated metastatic breast cancer (BC) patients, the reliable identification of PIK3CA …

The clinical outcome of patients with a diagnosis of hormone receptor (HR)+ breast cancer
has improved remarkably since the arrival of endocrine therapy. Yet, resistance to standard …