Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

The brain renin-angiotensin system (RAS) has available the necessary functional
components to produce the active ligands angiotensins II (AngII), angiotensin III …

Alzheimer's (AD) and Parkinson's (PD) diseases are neurodegenerative diseases presently
without effective drug treatments. AD is characterized by general cognitive impairment …

Why has Alzheimer's disease (AD) remained a conundrum today? The main reason is the
stagnation in understanding the origins of plaques and tangles. While they are widely …

Alzheimer's disease (AD) is a progressive neurodegenerative disease increasing in
frequency as life expectancy of the world's population increases. There are an estimated 5 …

Alzheimer's disease (AD) is commonly associated with noncognitive behavioral changes
(NCBCs). The authors systematically reviewed whether neuroimaging has helped with …

There are no drugs that halt the progression of any age-associated neurodegenerative
disease. This may be due to the failure of drug developers to recognize that while there are …

According to the dominant biomedical view, Alzheimer's disease (AD) has a precise,
necessary and unifying neurobiological cause, which distinguishes it from other …

There is no doubt that individuals, families, communities, and governments face an
enormous challenge in the growing number of persons with dementia in our societies …