The Role of TIM-3 and LAG-3 in the Microenvironment and Immunotherapy of Ovarian Cancer

M Kozłowski, D Borzyszkowska, A Cymbaluk-Płoska - Biomedicines, 2022 - mdpi.com
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The main
treatment options are surgical removal of the tumor and chemotherapy. Cancer treatment …

Long noncoding RNAs: glycolysis regulators in gynaecologic cancers

N Lv, S Shen, Q Chen, J Tong - Cancer Cell International, 2023 - Springer
The three most common gynaecologic cancers that seriously threaten female lives and
health are ovarian cancer, cervical cancer, and endometrial cancer. Glycolysis plays a vital …

Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic …

S Feng, H Yin, K Zhang, M Shan, X Ji, S Luo… - Journal of Ovarian …, 2022 - Springer
Background Ferroptosis and iron-metabolism are regulated by Long non-coding RNAs
(lncRNAs) in ovarian cancer (OC). Therefore, a comprehensive analysis of ferroptosis and …

Computed tomography imaging-based radiogenomics analysis reveals hypoxia patterns and immunological characteristics in ovarian cancer

S Feng, T Xia, Y Ge, K Zhang, X Ji, S Luo… - Frontiers in …, 2022 - frontiersin.org
Purpose The hypoxic microenvironment is involved in the tumorigenesis of ovarian cancer
(OC). Therefore, we aim to develop a non-invasive radiogenomics approach to identify a …

[HTML][HTML] LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells

Y Jin, J Qiu, X Lu, Y Ma, G Li - Oncology Research, 2023 - ncbi.nlm.nih.gov
Previous study revealed that ferritin heavy chain-1 (FTH1) could regulate ferritinophagy and
affect intracellular Fe 2+ content in various tumors, while its N6-methyladenosine (m6A) …

Construction of ovarian cancer prognostic model based on the investigation of ferroptosis-related lncRNA

S Yang, J Ji, M Wang, J Nie, S Wang - Biomolecules, 2023 - mdpi.com
(1) Background: Ovarian cancer (OV) has the high mortality rate among gynecological
cancers worldwide. Inefficient early diagnosis and prognostic prediction of OV leads to poor …

Transcriptional and post-transcriptional mechanisms that regulate the genetic program in Zika virus-infected macrophages

GJ Fernandez, JM Ramírez-Mejía… - The International Journal …, 2022 - Elsevier
Besides our understanding of the effects of ZIKA virus (ZIKV) infection on neural progenitors'
cells the pathogenesis of this RNA virus also involves antigen-presenting cells, including …

Derivation, comprehensive analysis, and assay validation of a pyroptosis-related lncRNA prognostic signature in patients with ovarian cancer

X Cao, Q Zhang, Y Zhu, X Huo, J Bao, M Su - Frontiers in oncology, 2022 - frontiersin.org
Background Pyroptosis is regulated by long non-coding RNAs (lncRNAs) in ovarian cancer
(OC). Therefore, a comprehensive analysis of pyroptosis-related lncRNAs (PRLs) in OC is …

Glycolysis induces Th2 cell infiltration and significantly affects prognosis and immunotherapy response to lung adenocarcinoma

L Zeng, L Liang, X Fang, S Xiang, C Dai… - Functional & Integrative …, 2023 - Springer
Glycolysis has a major role in cancer progression and can affect the tumor immune
microenvironment, while its specific role in lung adenocarcinoma (LUAD) remains poorly …

Development and verification of a 7-lncRNA prognostic model based on tumor immunity for patients with ovarian cancer

J Feng, Y Yu, W Yin, S Qian - Journal of Ovarian Research, 2023 - Springer
Background Both immune-reaction and lncRNAs play significant roles in the proliferation,
invasion, and metastasis of ovarian cancer (OC). In this study, we aimed to construct an …