Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Lysosomal dysfunction in neurodegeneration: emerging concepts and methods

V Udayar, Y Chen, E Sidransky, R Jagasia - Trends in neurosciences, 2022 - cell.com
The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …

The metabolomics of human aging: Advances, challenges, and opportunities

DJ Panyard, B Yu, MP Snyder - Science Advances, 2022 - science.org
As the global population becomes older, understanding the impact of aging on health and
disease becomes paramount. Recent advancements in multiomic technology have allowed …

[HTML][HTML] Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles

P Dowling, S Gargan, D Swandulla… - International Journal of …, 2023 - mdpi.com
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

[HTML][HTML] Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral …

H Babu, AT Ambikan, EE Gabriel… - Frontiers in …, 2019 - frontiersin.org
The ART program in low-and middle-income countries (LMIC) like India, follows a public
health approach with a standardized regimen for all people living with HIV (PLHIV). Based …

Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases

J Fu, LL Zhang, W Li, Y Zhang, Y Zhang, F Liu, L Zou - Food chemistry, 2022 - Elsevier
Metabolomics is an important branch of systems biology, which can detect changes in the
body's metabolism before and after the intervention of functional foods, identify effective …

The aging metabolome—biomarkers to hub metabolites

R Sharma, A Ramanathan - Proteomics, 2020 - Wiley Online Library
Aging biology is intimately associated with dysregulated metabolism, which is one of the
hallmarks of aging. Aging‐related pathways such as mTOR and AMPK, which are major …

[HTML][HTML] The roles and pharmacological effects of FGF21 in preventing aging-associated metabolic diseases

J Yan, Y Nie, J Cao, M Luo, M Yan, Z Chen… - Frontiers in …, 2021 - frontiersin.org
With the continuous improvement of living standards but the lack of exercise, aging-
associated metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and non …

Hippuric acid: Could became a barometer for frailty and geriatric syndromes?

G De Simone, C Balducci, G Forloni, R Pastorelli… - Ageing Research …, 2021 - Elsevier
Aging is a natural biological event that has some downsides such as increased frailty,
decline in cognitive and physical functions leading to chronical diseases, and lower quality …