Anti-amyloid therapies for Alzheimer's disease and the amyloid cascade hypothesis

E Fedele - International journal of molecular sciences, 2023 - mdpi.com
Over the past 30 years, the majority of (pre) clinical efforts to find an effective therapy for
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …

The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

Biochemical and molecular pathways in neurodegenerative diseases: an integrated view

N Sanghai, GK Tranmer - Cells, 2023 - mdpi.com
Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease
(PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex …

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

M Aili, K Zhou, J Zhan, H Zheng, F Luo - Journal of Materials Chemistry …, 2023 - pubs.rsc.org
Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive
dysfunction and reduces a person's decision-making and reasoning functions. AD is the …

Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Targeting CaN/NFAT in Alzheimer's brain degeneration

J Mackiewicz, M Lisek, T Boczek - Frontiers in Immunology, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of cognitive functions. While the exact causes of this debilitating disorder remain …

Current understanding of metal-dependent amyloid-β aggregation and toxicity

Y Yi, MH Lim - RSC Chemical Biology, 2023 - pubs.rsc.org
The discovery of effective therapeutics targeting amyloid-β (Aβ) aggregates for Alzheimer's
disease (AD) has been very challenging, which suggests its complicated etiology associated …

From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example

P Kumar, S Mathew, R Gamage, F Bodkin… - International Journal of …, 2023 - mdpi.com
The Australian rainforest is a rich source of medicinal plants that have evolved in the face of
dramatic environmental challenges over a million years due to its prolonged geographical …

Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy?

R Tarawneh - Biomolecules, 2023 - mdpi.com
Alzheimer disease (AD) models are based on the notion that abnormal protein aggregation
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …

The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics

K Li, H Ling, X Wang, Q Xie, C Gu, W Luo… - Progress in Neuro …, 2024 - Elsevier
Background Methamphetamine (METH) is a highly addictive stimulant that has become one
of the top five risk substances cause deaths from substance abuse. METH exposure …