R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular, subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show that technical noise produces …
I Bautmans, V Knoop, JA Thiyagarajan… - The lancet Healthy …, 2022 - thelancet.com
Intrinsic capacity, a crucial concept in healthy ageing, is defined by WHO as" the composite of all the physical and mental capacities that an individual can draw on at any point in time" …
Background and Objectives DNA methylation algorithms are increasingly used to estimate biological aging; however, how these proposed measures of whole-organism biological …
Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We …
T Pandics, D Major, V Fazekas-Pongor, Z Szarvas… - Geroscience, 2023 - Springer
The aging population worldwide is facing a significant increase in age-related non- communicable diseases, including cardiovascular and brain pathologies. This …
To define metrics of phenotypic aging, it is essential to identify biological and environmental factors that influence the pace of aging. Previous attempts to develop aging metrics were …
Background: Adolescence is a stage of fast growth and development. Exposures during puberty can have long-term effects on health in later life. This study aims to investigate the …
X Cao, Z Yang, X Li, C Chen, EO Hoogendijk, J Zhang… - BMC medicine, 2023 - Springer
Background Comorbidities among cancer survivors remain a serious healthcare burden and require appropriate management. Using two widely used frailty indicators, this study aimed …