Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …

Intervertebral disc degeneration is highly prevalent within the elderly population and is a
leading cause of chronic back pain and disability. Due to the link between disc degeneration …

Even though they would have great benefit across research and clinical fields, currently
there are no accepted biomarkers of frailty. Cross-sectional studies in humans have …

Studies on interventions that can delay or treat frailty in humans are limited. There is
evidence of beneficial effects of angiotensin converting enzyme (ACE) inhibitors on aspects …

Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …

Global average life expectancy continues to rise. As aging increases the likelihood of frailty,
which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for …

On average, aging is associated with unfavorable changes in cellular metabolism, which are
the processes involved in the storage and expenditure of energy. However, metabolic …

A frailty index (FI) based on clinical deficit accumulation (FI-Clinical) quantifies frailty in
aging mice. We aimed to develop a laboratory test-based murine FI tool (FI-Lab) and to …