Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which
accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …