High-grade gliomas are primary brain tumors that are incredibly refractory long-term to
surgery and chemoradiation, with no proven durable salvage therapies for patients that have …

Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

Introduction Chronic neuroinflammation can exist for months to years following traumatic
brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods …

Doxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced
cognitive impairments (chemobrain). Chemobrain is associated with inflammation and …

Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can
be obtained quickly, conveniently, and cheaply from blood samples. However, there is no …

Background It is well established that traumatic brain injury (TBI) causes acute and chronic
alterations in systemic immune function and that systemic immune changes contribute to …

Traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune
function which contribute to posttraumatic neuroinflammation and neurodegeneration …

Environmental and occupational exposure to hazardous substances accelerates biological
aging. However, the toxic effects of nanomaterials on telomere and cellular senescence …

There are sex differences in vulnerability and resilience to the stressors of aging and
subsequent age-related cognitive decline. Cellular senescence occurs as a response to …

In contrast to the hypothesis that aging results from cell-autonomous deterioration
processes, the programmed longevity theory proposes that aging arises from a partial …