T cells in tick-borne Flavivirus encephalitis: a review of current paradigms in protection and disease pathology

ET Stone, AK Pinto - Viruses, 2023 - mdpi.com
The family Flaviviridae is comprised of a diverse group of arthropod-borne viruses that are
the etiological agents of globally relevant diseases in humans. Among these, infection with …

B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis

A Cardani‐Boulton, BT Boylan… - Immunological …, 2022 - Wiley Online Library
A diverse number of DNA and RNA viruses have the potential to invade the central nervous
system (CNS), causing inflammation and injury to cells that have a limited capacity for repair …

Immunoinformatics and computational approaches driven designing a novel vaccine candidate against Powassan virus

TL Nguyen, H Kim - Scientific Reports, 2024 - nature.com
Powassan virus (POWV) is an arthropod-borne virus (arbovirus) capable of causing severe
illness in humans for severe neurological complications, and its incidence has been on the …

Characterization of live-attenuated Powassan virus vaccine candidates identifies an efficacious prime-boost strategy for mitigating Powassan virus disease in a murine …

AM Cheung, EZ Yip, AW Ashbrook, N Goonawardane… - Vaccines, 2023 - mdpi.com
Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in
humans. The lack of treatment or prevention strategies for POWV disease underscores the …

Intermediate levels of pre-existing protective antibody allow priming of protective T cell immunity against influenza

T Ng, V Flores-Malavet, MAM Mansoor… - The Journal of …, 2023 - journals.aai.org
Overcoming interfering impacts of pre-existing immunity to generate universally protective
influenza A virus (IAV)-specific T cell immunity through vaccination is a high priority. In this …

Upsurge of Powassan virus disease in northeastern United States: a public health concern—a short communication

H Anis, AB Shaik, E Karabulut, M Uzun… - Annals of Medicine …, 2023 - journals.lww.com
Powassan virus (POWV) is a tick-borne Flavivirus primarily transmitted through ticks in North
America which is a significant public health threat in the northeastern United States. POWV …

Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of Oas1b

BA Jasperse, MD Mattocks, KE Noll, MT Ferris… - Journal of …, 2023 - Am Soc Microbiol
Powassan virus (POWV) is an emerging tick-borne flavivirus that causes neuroinvasive
diseases, including encephalitis, meningitis, and paralysis. Similar to other neuroinvasive …

A Circuitous Journey of Virus Characterization and Surveillance in North and Central America

RJ McMinn - 2023 - search.proquest.com
The burden of ticks and the pathogens they carry is increasing worldwide. Powassan virus
(POWV, Flaviviridae: Flavivirus), the only known North American tick-borne flavivirus, is of …

Murine Models of Powassan Virus Disease Reveal a Role for T Cells in Protection and Pathogenesis

ET Stone - 2023 - search.proquest.com
Powassan virus (POWV) is a tick-borne flavivirus which causes fatal meningoencephalitis in
10-15% of reported human cases, but for which there are no approved vaccinations or …

[HTML][HTML] Titration and neutralizing antibody quantification by focus forming assay for Powassan virus

ET Stone, AJ Hirsch, JL Smith, JD Brien, AK Pinto - STAR protocols, 2022 - Elsevier
The development of high-throughput assays measuring Powassan virus (POWV) lineage I
and II represents an important step in virological and immunological studies. By adapting …