The normative modeling framework for computational psychiatry

S Rutherford, SM Kia, T Wolfers, C Fraza, M Zabihi… - Nature protocols, 2022 - nature.com
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …

Site effects how-to and when: An overview of retrospective techniques to accommodate site effects in multi-site neuroimaging analyses

JMM Bayer, PM Thompson, CRK Ching, M Liu… - Frontiers in …, 2022 - frontiersin.org
Site differences, or systematic differences in feature distributions across multiple data-
acquisition sites, are a known source of heterogeneity that may adversely affect large-scale …

Evidence for embracing normative modeling

S Rutherford, P Barkema, IF Tso, C Sripada… - Elife, 2023 - elifesciences.org
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …

Charting brain growth and aging at high spatial precision

S Rutherford, C Fraza, R Dinga, SM Kia, T Wolfers… - elife, 2022 - elifesciences.org
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …

[HTML][HTML] Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation

R Ge, Y Yu, YX Qi, Y Fan, S Chen, C Gao… - The Lancet Digital …, 2024 - thelancet.com
The value of normative models in research and clinical practice relies on their robustness
and a systematic comparison of different modelling algorithms and parameters; however …

Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression

SM Kia, H Huijsdens, S Rutherford, A de Boer, R Dinga… - Plos one, 2022 - journals.plos.org
Clinical neuroimaging data availability has grown substantially in the last decade, providing
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …

A hybrid extreme learning machine and deep belief network framework for sludge bulking monitoring in a dynamic wastewater treatment process

U Safder, J Loy-Benitez, HT Nguyen, CK Yoo - Journal of Water Process …, 2022 - Elsevier
In biological wastewater treatment plants (WWTPs), sludge thickening is a common problem
with major economic and environmental effects. Monitoring the sludge volume index (SVI) is …

Normative modeling of neuroimaging data using generalized additive models of location scale and shape

R Dinga, CJ Fraza, JMM Bayer, SM Kia, CF Beckmann… - BioRxiv, 2021 - biorxiv.org
Normative modeling aims to quantify the degree to which an individual's brain deviates from
a reference sample with respect to one or more variables, which can be used as a potential …

[HTML][HTML] Normative models for neuroimaging markers: Impact of model selection, sample size and evaluation criteria

J Bozek, L Griffanti, S Lau, M Jenkinson - NeuroImage, 2023 - Elsevier
Modelling population reference curves or normative modelling is increasingly used with the
advent of large neuroimaging studies. In this paper we assess the performance of fitting …

[HTML][HTML] Deviations from normative brain white and gray matter structure are associated with psychopathology in youth

R Kjelkenes, T Wolfers, D Alnæs, LB Norbom… - Developmental …, 2022 - Elsevier
Combining imaging modalities and metrics that are sensitive to various aspects of brain
structure and maturation may help identify individuals that show deviations in relation to …