The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …

Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …

In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases
nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and …

Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …

Objective: Major depressive disorder is associated with an increased risk of mortality and
aging-related diseases. The authors examined whether major depression is associated with …

Alternative pre-mRNA splicing increases the complexity of the proteome that can be
generated from the available genomic coding sequences. Dysregulation of the splicing …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …