SARS-CoV-2: structure, biology, and structure-based therapeutics development

MY Wang, R Zhao, LJ Gao, XF Gao… - Frontiers in cellular …, 2020 - frontiersin.org
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has been posing great threats to the world in many aspects. Effective therapeutic and …

[HTML][HTML] Characteristics of SARS-CoV-2 and COVID-19

B Hu, H Guo, P Zhou, ZL Shi - Nature reviews microbiology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute …

Age-dependent immune response to the Biontech/Pfizer BNT162b2 coronavirus disease 2019 vaccination

L Müller, M Andrée, W Moskorz, I Drexler… - Clinical Infectious …, 2021 - academic.oup.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
has led to the development of various vaccines. Real-life data on immune responses elicited …

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind …

Z Wu, Y Hu, M Xu, Z Chen, W Yang, Z Jiang… - The Lancet Infectious …, 2021 - thelancet.com
Background A vaccine against COVID-19 is urgently needed for older adults, in whom
morbidity and mortality due to the disease are increased. We aimed to assess the safety …

Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies

BG Pijls, S Jolani, A Atherley, RT Derckx, JIR Dijkstra… - BMJ open, 2021 - bmjopen.bmj.com
Objective We aimed to describe the associations of age and sex with the risk of COVID-19 in
different severity stages ranging from infection to death. Design Systematic review and meta …

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus

KM Bubar, K Reinholt, SM Kissler, M Lipsitch, S Cobey… - Science, 2021 - science.org
Limited initial supply of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccine raises the question of how to prioritize available doses. We used a mathematical …

Accelerated biological aging in COVID-19 patients

X Cao, W Li, T Wang, D Ran, V Davalos… - Nature …, 2022 - nature.com
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

S Abu-Rumeileh, A Abdelhak, M Foschi, H Tumani… - Journal of …, 2021 - Springer
Abstract Since coronavirus disease-2019 (COVID-19) outbreak in January 2020, several
pieces of evidence suggested an association between the spectrum of Guillain–Barré …

Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis

M Yanes-Lane, N Winters, F Fregonese, M Bastos… - PloS one, 2020 - journals.plos.org
Background The study objective was to conduct a systematic review and meta-analysis on
the proportion of asymptomatic infection among coronavirus disease 2019 (COVID-19) …

Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review

A Izcovich, MA Ragusa, F Tortosa, MA Lavena Marzio… - PloS one, 2020 - journals.plos.org
Background and purpose The objective of our systematic review is to identify prognostic
factors that may be used in decision-making related to the care of patients infected with …