Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

Social disadvantage and diet composition independently impact myriad dimensions of
health. They are closely entwined, as social disadvantage often yields poor diet quality, and …

Aging is widespread worldwide and a significant risk factor for cardiovascular disease
(CVD). Mechanisms underlying aging have attracted considerable attention in recent years …

Social gradients in health and aging have been reported in studies across many human
populations, and-as the papers included in this special collection highlight–also occur …

Preclinical models have been the backbone of translational research for more than a
century. Rats and mice are critical models in the preliminary stages of drug testing, both for …

Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse
mental health outcomes later in life increasing the risk of several psychiatric disorders …

抄録 エピゲノムは, 外的環境やストレスに応じて適切に遺伝子のオンとオフを制御する機能を持って
いる. 近年, DNA メチル化やヒストン修飾, クロマチンリモデリングなどによるエピゲノムは …