Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature Reviews Genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

[HTML][HTML] The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

The contribution of the exposome to the burden of cardiovascular disease

T Münzel, M Sørensen, O Hahad… - Nature Reviews …, 2023 - nature.com
Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …

[HTML][HTML] Time to consider the “exposome hypothesis” in the development of the obesity pandemic

V Catalán, I Avilés-Olmos, A Rodríguez, S Becerril… - Nutrients, 2022 - mdpi.com
The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with
a dramatic decline in physical activity are the alleged main causes for this pandemic. While …

Internal exposure and distribution of airborne fine particles in the human body: methodology, current understandings, and research needs

W Wang, Y Lin, H Yang, W Ling, L Liu… - Environmental …, 2022 - ACS Publications
Exposure to airborne fine particles (PM2. 5, particulate matter with aerodynamic diameter<
2.5 μm) severely threatens global human health. Understanding the distribution and …

A systematic review of polycyclic aromatic hydrocarbon derivatives: Occurrences, levels, biotransformation, exposure biomarkers, and toxicity

B Peng, Q Dong, F Li, T Wang, X Qiu… - Environmental Science & …, 2023 - ACS Publications
Polycyclic aromatic hydrocarbon (PAH) derivatives constitute a significant class of emerging
contaminants that have been ubiquitously detected in diverse environmental matrixes, with …

[HTML][HTML] Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome

KE Manz, A Feerick, JM Braun, YL Feng… - Journal of Exposure …, 2023 - nature.com
Non-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques
that rely on high-resolution mass spectrometry (HRMS) and computational tools to detect …

Omics technologies in allergy and asthma research: An EAACI position paper

U Radzikowska, K Baerenfaller, JA Cornejo‐Garcia… - Allergy, 2022 - Wiley Online Library
Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

[HTML][HTML] A dynamic concept of animal welfare: The role of appetitive and adverse internal and external factors and the animal's ability to adapt to them

SS Arndt, VC Goerlich, FJ van der Staay - Frontiers in Animal Science, 2022 - frontiersin.org
Animal welfare is a multifaceted issue that can be approached from different viewpoints,
depending on human interests, ethical assumptions, and culture. To properly assess …

[HTML][HTML] Integrating the social environment with an equity perspective into the exposome paradigm: a new conceptual framework of the Social Exposome

H Gudi-Mindermann, M White, J Roczen, N Riedel… - Environmental …, 2023 - Elsevier
The importance of the social environment and social inequalities in disease etiology is well-
known due to the profound research and conceptual framework on social determinants of …