Water solubility and low bioavailability of active pharmaceutical ingredients are some of the
main challenges in the process of developing new drugs, especially drugs in oral solid …

Flavonoids are of interest for pharmacy and medicinal chemistry due to a wide range of
biological activities. The major goal for the design of new drugs based on flavonoids is to …

Co-crystallization is a promising approach for improving physical and pharmacological
properties of API, viz., solubility, dissolution rate, stability, hygroscopicity, tablet ability …

This report explores the antioxidant interaction of combinations of flavonoid–glutathione with
different ratios. Two different 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical …

Piperine, a secondary metabolite of Piper nigrum L., has been known for its pharmacological
activities. However, the use of piperine is still limited due to the low solubility in water. The …

Understanding drug cocrystal formation and its competitive mechanism is important for
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …

Loratadine belongs to second generation antihistamine (H1) drug and is known to form
cocrystal with succinic acid in stoichiometry of 1: 1 using slurry method. This study was …

Background: Quercetin (3, 3', 4', 5, 7-pentahydroxil-flavon) is a flavone and secondary
metabolite known as flavonoid. Quercetin belongs to class II BCS that has low solubility and …

Objectives Loratadine belongs to Class II compound of biopharmaceutics classification
system (BCS) due its low solubility and high membrane permeability. Cocrystal is a system …

Phytochemicals have been used to reduce the risk of diseases and maintain good health
and well-being. However, most phytochemicals have a limitation in their physicochemical …