Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative
damage and inflammation are pathognomonic features of Parkinson's disease (PD) and …

Both physiological and pathological aging processes induce brain alterations especially
affecting the speed of processing, working memory, conceptual reasoning and executive …

Mesenchymal stem-cell-derived small extracellular vesicles (MSC-EVs), as a therapeutic
agent, have shown great promise in the treatment of neurological diseases. To date, the …

Parkinson's disease (PD) is a tricky neurodegenerative disease characterized with motor
deficits and gastrointestinal (GI) dysfunction. Gut microbiota disturbance is reported to be …

The objective of this study was to improve effectiveness of resveratrol (RES) through brain
targeting by the intranasal olfactory mucosa for the treatment Alzheimer's disease (AD). To …

Vitis vinifera (grape) contains various compounds with acknowledged phytochemical and
pharmacological properties. Among the different parts of the plant, pomace is of particular …

It is important to monitor the aggregation process of amyloid protein for fundamental
researches, diagnosis and drug development of the related diseases, like …

Abstract The World Health Organization predicts that by 2050, 2.1 billion people worldwide
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …

As natural functional bioactive ingredients found in foods and plants, polyphenols play
various antioxidant and anti-inflammatory roles to prevent the development of disease and …

Traumatic brain injury (TBI) has become one of the most important causes of death and
disability worldwide. A series of neuroinflammatory responses induced after TBI are key …