Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

[HTML][HTML] Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

On the path to 2025: understanding the Alzheimer's disease continuum

PS Aisen, J Cummings, CR Jack, JC Morris… - Alzheimer's research & …, 2017 - Springer
Basic research advances in recent years have furthered our understanding of the natural
history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes …

Detection and treatment of Alzheimer's disease in its preclinical stage

MS Rafii, PS Aisen - Nature Aging, 2023 - nature.com
Longitudinal multimodal biomarker studies reveal that the continuum of Alzheimer's disease
(AD) includes a long latent phase, referred to as preclinical AD, which precedes the onset of …

Drugs in clinical trials for Alzheimer's disease: the major trends

SO Bachurin, EV Bovina… - Medicinal research …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

[HTML][HTML] The P2X7 receptor: central hub of brain diseases

R Andrejew, Á Oliveira-Giacomelli… - Frontiers in Molecular …, 2020 - frontiersin.org
The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Tau positron emission tomographic imaging in the Lewy body diseases

SN Gomperts, JJ Locascio, SJ Makaretz… - JAMA …, 2016 - jamanetwork.com
Importance The causes of cognitive impairment in dementia with Lewy bodies (DLB) and
Parkinson disease (PD) are multifactorial. Tau pathologic changes are commonly observed …

Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model

M Cai, JH Lee, EJ Yang - Journal of Neuroinflammation, 2019 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
progressive loss of cognitive abilities and memory leading to dementia. Electroacupuncture …