Reduced Expression of Voltage‐Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1‐42

S Li, GJ Yan, YX Tan, LL Xue, TH Wang… - Neural …, 2022 - Wiley Online Library
Voltage‐gated sodium channel beta 2 (Nav2. 2 or Navβ2, coded by SCN2B mRNA), a gene
involved in maintaining normal physiological functions of the prefrontal cortex and …

[HTML][HTML] Adipose tissue-derived mesenchymal stem cells alter metabolites of brain cholesterol homeostasis in an alzheimer's model

MK Darabi, Z Nazeri, A Rafeeinia… - Cell Journal …, 2023 - ncbi.nlm.nih.gov
Objective: Disruption of cholesterol homeostasis in Alzheimer's disease (AD) plays a crucial
role in disease pathogenesis, making it a potential therapeutic target. Mesenchymal stem …

Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual‐hit hypothesis of neurodegeneration

SD Heinemann, JM Posimo, DM Mason… - …, 2016 - Wiley Online Library
The dual‐hit hypothesis of neurodegeneration states that severe stress sensitizes
vulnerable cells to subsequent challenges so that the two hits are synergistic in their toxic …

Untold new beginnings: adult hippocampal neurogenesis and Alzheimer's disease

CM Teixeira, N Pallas-Bazarra, M Bolós… - Journal of …, 2018 - content.iospress.com
Neurogenesis occurs in a limited number of brain regions during adulthood. Of these, the
hippocampus has attracted great interest due to its involvement in memory processing …

[HTML][HTML] Fiberoptic hemodynamic spectroscopy reveals abnormal cerebrovascular reactivity in a freely moving mouse model of Alzheimer's disease

DS Gareau, N RochaKim, A Choudhury… - Frontiers in Molecular …, 2023 - frontiersin.org
Many Alzheimer's disease (AD) patients suffer from altered cerebral blood flow and
damaged cerebral vasculature. Cerebrovascular dysfunction could play an important role in …

A functional assessment tool to distinguish controls from Alzheimer's disease in Lima, Peru

N Custodio, R Montesinos… - American Journal of …, 2022 - journals.sagepub.com
Background The Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-
ADL) scale is a versatile functional assessment tool for patients with Alzheimer's disease …

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases–Current Insights

A Sekar, MTN Panouillères, D Kaski - Eye and Brain, 2024 - Taylor & Francis
This review delineates the ocular motor disturbances across a spectrum of
neurodegenerative disorders, including Alzheimer's Disease (AD) and related disorders …

[PDF][PDF] Cholinesterase inhibitors and non-steroidal anti-inflammatory drugs as Alzheimer's disease therapies: an updated umbrella review of systematic reviews and …

CH Wang, LS Wang, N Zhu - Eur Rev Med Pharmacol Sci, 2016 - europeanreview.org
OBJECTIVE: Alzheimer's Disease (AD) is a major neurological disorder marked by an
amyloid-beta plaque and neurofibrillary tau-tangle depositions in the brain. Cognitive …

In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease

XM Hu, W Dong, ZW Cui, CZ Gao, ZJ Yu… - Journal of molecular …, 2018 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disease of the elderly that
seriously affects the quality of life and the life expectancy of those affected. There is, as yet …

[HTML][HTML] A super-resolved view of the Alzheimer's disease-related amyloidogenic pathway in hippocampal neurons

Y Yu, Y Gao, B Winblad, LO Tjernberg… - Journal of …, 2021 - content.iospress.com
Background: Processing of the amyloid-β protein precursor (AβPP) is neurophysiologically
important due to the resulting fragments that regulate synapse biology, as well as potentially …