Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

It is widely acknowledged that infectious diseases have wrought immense havoc on human
society, being regarded as adversaries from which humanity cannot elude. In recent years …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Conventional methods fall short in unraveling the dynamics of rare cell types related to
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …

The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the
brain is a highly interconnected integrative hub for sensory and spatial information; it also …

Fibroblasts are important regulators of inflammation, but whether fibroblasts change
phenotype during resolution of inflammation is not clear. Here we use positron emission …

Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of
insulin-producing pancreatic islet beta cells. Despite significant advancements, the precise …

Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …

Midbrain dopamine (mDA) neurons comprise diverse cells with unique innervation targets
and functions. This is illustrated by the selective sensitivity of mDA neurons of the substantia …

The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable
factors, with remarkable differences evident between individuals at the molecular level. Here …