Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of pathologically
activated, mostly immature, myeloid cells that exert robust immunosuppressive functions …

Conspectus Cancer stem cells (CSCs), also known as tumor initiating cells or tumor
repopulating cells, which comprise only a small fraction of tumor, have received tremendous …

Background Conventional immunohistochemistry technologies were limited by the inability
to simultaneously detect multiple markers and the lack of identifying spatial relationships …

Cancer vaccines show huge potential for cancer prevention and treatment. However, their
efficacy remains limited due to weak immunogenicity regarding inefficient stimulation of …

Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational
points in the EGFR gene have significantly reduced suffering and provided greater relief to …

Intra-tumoral immune cells promote the stemness of cancer stem cells (CSCs) in the tumor
microenvironment (TME). CSCs promote tumor progression, relapse, and resistance to …

Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain
unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer mortality worldwide. Colitis-associated colorectal cancer (CAC) is a subtype …