Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

There is a growing realization that some aging-associated phenotypes/diseases have an
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics …

Background Gestational age is often used as a proxy for developmental maturity by
clinicians and researchers alike. DNA methylation has previously been shown to be …

Mendelian randomization (MR) is an approach that uses genetic variants associated with a
modifiable exposure or biological intermediate to estimate the causal relationship between …

DNA methylation patterns are altered in numerous diseases and often correlate with
clinically relevant information such as disease subtypes, prognosis and drug response. With …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell
differentiation program by whole-genome bisulfite sequencing and high-density microarrays …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental
disorders. Although the aetiology of ASD has a strong genetic component, there is …