Bisulfite sequencing measures absolute levels of DNA methylation at single-nucleotide
resolution, providing a robust platform for molecular diagnostics. We optimized bisulfite …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

DNA methylation plays an important role in both normal human development and risk of
disease. The most utilized method of assessing DNA methylation uses BeadChips …

The proper identification of differentially methylated CpGs is central in most epigenetic
studies. The Illumina HumanMethylation450 BeadChip is widely used to quantify DNA …

Motivation: A common difficulty in large-scale microarray studies is the presence of
confounding factors, which may significantly skew estimates of statistical significance, cause …

Liver cancer is the third leading cause of cancer-related death worldwide. Advances in
sequencing technologies have enabled the examination of liver cancer genomes at high …

Given the global increase in air pollution and its crucial role in human health, as well as the
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …

Abstract Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived
tumours with a very strong genetic component. Here we report the first integrated genomic …

Diagnosis of primary brain tumors relies heavily on histopathology. Although various
computational pathology methods have been developed for automated diagnosis of primary …

Epigenetic changes are widely considered to play an important role in aging, but
experimental evidence to support this hypothesis has been scarce. We have used array …