During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …

Identification of host determinants of coronavirus infection informs mechanisms of viral
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian …

Aging is a major risk factor for many diseases, especially in highly prevalent
cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease …

Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …

SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a
large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is …

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …