Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …
Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense of homeostasis and the functional and …
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …
Y Sato, K Atarashi, DR Plichta, Y Arai, S Sasajima… - Nature, 2021 - nature.com
Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases 1, 2, 3. Here we show that centenarians have a distinct …
Ageing leads to profound alterations in the immune system and increases susceptibility to some chronic, infectious and autoimmune diseases. In recent years, widespread application …
X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …