Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Post-acute sequelae of COVID-19: Evidence of mood & cognitive impairment

SJ Lamontagne, MF Winters, DA Pizzagalli… - Brain, Behavior, & …, 2021 - Elsevier
Acute health consequences associated with coronavirus disease 2019 (COVID-19) infection
have been thoroughly characterized; however, long-term impacts are not yet understood …

Hyperinflammatory response in COVID-19: a systematic review

MJA Silva, LR Ribeiro, MIM Gouveia, BR Marcelino… - Viruses, 2023 - mdpi.com
COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal

GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Abstract In coronavirus disease 2019 (Covid-19) era, neuroinflammation may develop due
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …

[HTML][HTML] SARS-CoV-2 infection and multi-organ system damage: A review

AA Rabaan, S Smajlović, H Tombuloglu… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred
million people globally as of 8 2022. Organs and cells harboring angiotensin-converting …

Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain

H Hernández-Parra, OD Reyes-Hernández… - Frontiers in Cellular …, 2023 - frontiersin.org
Diverse neurological symptoms have been reported in patients with SARS-CoV-2 disease
(COVID-19), including stroke, ataxia, meningitis, encephalitis, and cognitive impairment …

Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …

Can SARS-CoV-2 infection lead to neurodegeneration and Parkinson's disease?

L Krey, MK Huber, GU Höglinger, F Wegner - Brain Sciences, 2021 - mdpi.com
The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since
2020. Links between the newly discovered viral infection and the pathogenesis of …

COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …