Bridging biological cfDNA features and machine learning approaches

T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …

[HTML][HTML] Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy

L Sivapalan, JC Murray, JVL Canzoniero… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Circulating cell-free tumor DNA (ctDNA) can serve as a real-time biomarker of tumor burden
and provide unique insights into the evolving molecular landscape of cancers under the …

Melanoma segmentation: A framework of improved DenseNet77 and UNET convolutional neural network

M Nawaz, T Nazir, M Masood, F Ali… - … Journal of Imaging …, 2022 - Wiley Online Library
Melanoma is the most fatal type of skin cancer which can cause the death of victims at the
advanced stage. Extensive work has been presented by the researcher on computer vision …

Potential clinical utility of liquid biopsy in early-stage non-small cell lung cancer

H Shen, Y Jin, H Zhao, M Wu, K Zhang, Z Wei, X Wang… - BMC medicine, 2022 - Springer
Background Liquid biopsy has been widely researched for early diagnosis, prognostication
and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for …

The functional and clinical roles of liquid biopsy in patient-derived models

Z Zhu, E Hu, H Shen, J Tan, S Zeng - Journal of Hematology & Oncology, 2023 - Springer
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

Five-year clinical outcomes after neoadjuvant nivolumab in resectable non–small cell lung cancer

S Rosner, JE Reuss, M Zahurak, J Zhang, Z Zeng… - Clinical Cancer …, 2023 - AACR
Abstract Purpose: Neoadjuvant anti–PD-1 therapy has shown promise for resectable non–
small cell lung cancer (NSCLC). We reported the first phase I/II trial of neoadjuvant …

Perioperative targeted therapy for oncogene-driven NSCLC

SY Liu, JT Zhang, KH Zeng, YL Wu - Lung Cancer, 2022 - Elsevier
Targeted therapy has stepped into the perioperative treatment arena and launched a radical
revolution in the treatment of early-stage oncogene-driven non-small-cell lung cancer …

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients

PS Chauhan, A Shiang, I Alahi, RT Sundby… - NPJ Precision …, 2023 - nature.com
Circulating tumor DNA (ctDNA) sensitivity remains subpar for molecular residual disease
(MRD) detection in bladder cancer patients. To remedy this problem, we focused on the …

Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II–IIIA …

DCL Vessies, MMF Schuurbiers… - Molecular …, 2022 - Wiley Online Library
Stage II–IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy
after surgery as standard‐of‐care treatment, even though only approximately 5.8% of …

CD4 T cells and toxicity from immune checkpoint blockade

N Earland, W Zhang, A Usmani, A Nene… - Immunological …, 2023 - Wiley Online Library
Immune‐related toxicities, otherwise known as immune‐related adverse events (irAEs),
occur in a substantial fraction of cancer patients treated with immune checkpoint inhibitors …