SARS-CoV-2 infection dysregulates NAD metabolism

A Izadpanah, JC Mudd, JGN Garcia… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe COVID-19 results initially in pulmonary infection and inflammation.
Symptoms can persist beyond the period of acute infection, and patients with Post-Acute …

IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

M Glaß, S Hüttelmaier - Viruses, 2023 - mdpi.com
The oncofetal RNA-binding protein IGF2BP1 has been reported to be a driver of tumor
progression in a multitude of cancer entities. Its main function is the stabilization of target …

Heparin inhibits SARS-CoV-2 replication in human nasal epithelial cells

LYY Lee, R Suryadinata, C McCafferty, V Ignjatovic… - Viruses, 2022 - mdpi.com
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by
social and public health measures, has proven efficacious for reducing disease severity and …

Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells

L Du, MS Bouzidi, A Gala, F Deiter… - Journal of Molecular …, 2023 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused
a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β …

Inhibition of the cellular deubiquitinase UCHL1 suppresses SARS-CoV-2 replication

B Subramaniyan, JL Larabee, M Bodas… - American Journal of …, 2023 - atsjournals.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for
coronavirus disease (COVID-19), a global pandemic with a significant mortality rate …

The isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for the study of SARS-CoV-2 host-virus interactions

B Subramaniyan, S Gurung, M Bodas, AR Moore… - Viruses, 2023 - mdpi.com
The mucociliary airway epithelium lines the human airways and is the primary site of host-
environmental interactions in the lung. Following virus infection, airway epithelial cells …

SARS‐C o V‐2‐infected human airway epithelial cell cultures uniquely lack interferon and immediate early gene responses caused by other coronaviruses

Y Wang, M Thaler, C Salgado‐Benvindo… - Clinical & …, 2024 - Wiley Online Library
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of
a class of highly pathogenic coronaviruses. The large family of coronaviruses, however, also …

[HTML][HTML] Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of …

TWM Crozier, EJD Greenwood… - Wellcome Open …, 2022 - ncbi.nlm.nih.gov
Background: Quantitative proteomics is able to provide a comprehensive, unbiased
description of changes to cells caused by viral infection, but interpretation may be …

Crowdsourcing temporal transcriptomic coronavirus host infection data: Resources, guide, and novel insights

J Flynn, MM Ahmadi, CT McFarland… - Biology Methods and …, 2023 - academic.oup.com
The emergence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2)
reawakened the need to rapidly understand the molecular etiologies, pandemic potential …

Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS‐CoV‐2 infection and COVID‐19 disease severity

PR Tedbury, C Manfredi, F Degenhardt… - The FASEB …, 2023 - Wiley Online Library
Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially
considered among those at highest risk for serious harm from SARS‐CoV‐2 infection …