Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Aging is a major risk factor for numerous human pathologies, including cardiovascular,
metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's
disease is increased age. Therefore, understanding the changes that occur as a result of …

Heart failure (HF) is a clinical syndrome that usually develops in the elderly. Complex
interactions of the cardiovascular aging process with risk factors (obesity, hypertension, and …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Diabetes is becoming one of the most widespread health burning problems in the elderly.
Worldwide prevalence of diabetes among subjects over 65 years was 123 million in 2017, a …

Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …

Aims/hypothesis Metformin use has been associated with reduced incidence of dementia in
diabetic individuals in observational studies. However, the causality between the two in the …