Icariin (ICA), a major flavonoid extracted from the Chinese tonic herb Epimedium, exerts
beneficial effects in a variety of age-dependent diseases, such as Alzheimer's disease (AD) …

Age-associated alterations of the immune system, which known as “immunosenescence”, is
characterized by a decline in innate and adaptive immunity, which leading to increased …

This perspectives article discusses the use of a novel set of dynamical biomarkers in the
assessment of biological versus chronological age. The basis for this development is a …

Biological aging is the correlated decline of multi-organ system integrity central to the
etiology of many age-related diseases. A novel epigenetic measure of biological aging …

Aging represents the greatest risk factor for chronic diseases and mortality, but to
understand it we need the ability to measure biological age. In recent years, many machine …

Our previous study demonstrated that the expression of sodium channel voltage‑gated beta
2 (SCN2B) increased with aging in senescence‑accelerated mouse prone 8 (SAMP8) mice …

The anti‐senescence function of genistein is related to inhibiting oxidative stress, however,
the mechanism has not been clarified. The present study aimed to explore the effects of …

Although demographic statistics show that populations around the world are rapidly ageing,
this rising life expectancy is accompanied by an increase in the number of people living with …

Aging researchers have been studying frailty for decades. Experts agree that frailty is a
medical syndrome marked by reduced physiologic function, which increases the risk of …

Importance Many older adults with depression do not experience remission with
antidepressant treatment, and markers of cellular senescence in late-life depression (LLD) …