[HTML][HTML] The molecular and systems biology of memory

ER Kandel, Y Dudai, MR Mayford - Cell, 2014 - cell.com
Learning and memory are two of the most magical capabilities of our mind. Learning is the
biological process of acquiring new knowledge about the world, and memory is the process …

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

[HTML][HTML] The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

ER Kandel - Molecular brain, 2012 - Springer
The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE,
CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the …

[HTML][HTML] Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder

N Eissa, M Al-Houqani, A Sadeq, SK Ojha… - Frontiers in …, 2018 - frontiersin.org
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

Epigenetic regulation in psychiatric disorders

N Tsankova, W Renthal, A Kumar… - Nature Reviews …, 2007 - nature.com
Many neurological and most psychiatric disorders are not due to mutations in a single gene;
rather, they involve molecular disturbances entailing multiple genes and signals that control …

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

T Kuwabara, J Hsieh, A Muotri, G Yeo… - Nature …, 2009 - nature.com
In adult hippocampus, new neurons are continuously generated from neural stem cells
(NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive. We …

[PDF][PDF] An essential switch in subunit composition of a chromatin remodeling complex during neural development

J Lessard, JI Wu, JA Ranish, M Wan, MM Winslow… - Neuron, 2007 - cell.com
Mammalian neural stem cells (NSCs) have the capacity to both self-renew and to generate
all the neuronal and glial cell-types of the adult nervous system. Global chromatin changes …

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

F Ye, Y Chen, TN Hoang, RL Montgomery, X Zhao… - Nature …, 2009 - nature.com
Oligodendrocyte development is regulated by the interaction of repressors and activators in
a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 …

[HTML][HTML] The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective

B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

E Korb, M Herre, I Zucker-Scharff, RB Darnell… - Nature …, 2015 - nature.com
Precise regulation of transcription is crucial for the cellular mechanisms underlying memory
formation. However, the link between neuronal stimulation and the proteins that directly …