Hematopoietic stem cells (HSC) produce all blood cell lineages by virtue of their capacity to
self-renew and differentiate into progenitors with decreasing cellular potential. Recent …

The central nervous system (CNS) is composed of three major cell types–neurons,
astrocytes, and oligodendrocytes–which differentiate from common multipotent neural stem …

Epigenetic mechanisms have recently been known to play fundamental roles in the
regulation of synaptic plasticity, and learning and memory tasks in many brain regions, such …

The repressor element 1 (RE-1)-silencing transcription factor (REST), also known as the
neuron-restrictive silencer factor (NRSF), was originally discovered as a transcriptional …

In the developing mammalian nervous system, common progenitors integrate both cell
extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types …

Extracellular signals and cell-intrinsic transcription factors cooperatively instruct generation
of diverse neurons. However, little is known about how neural progenitors integrate both …

The vertebrate brain is highly complex with millions to billions of neurons. During
development, the neural plate border region gives rise to the neural crest, cranial placodes …

Epigenetic regulatory complexes play key roles in the modulation of transcriptional
regulation underlying neural stem cell (NSC) proliferation and progeny specification. How …

The transient exposure of immature rodents to ethanol during postnatal day 7 (P7),
comparable to a time point within the third trimester of human pregnancy, induces …

During spinal cord development, the combination of secreted signaling proteins and
transcription factors provides information for each neural type differentiation. Studies using …