Hallmarks of the aging T‐cell system

H Zhang, CM Weyand, JJ Goronzy - The FEBS journal, 2021 - Wiley Online Library
The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

T cell fate decisions during memory cell generation with aging

I Sturmlechner, A Jain, Y Mu, CM Weyand… - Seminars in …, 2023 - Elsevier
The defense against infectious diseases, either through natural immunity or after
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …

RNA-interference-mediated aphid control in crop plants: a review

J Zhang, H Li, X Zhong, J Tian, A Segers, L Xia… - Agriculture, 2022 - mdpi.com
Crop plants suffer severe yield losses due to the significant damages caused by aphids.
RNA interference (RNAi) technology is a versatile and environmentally friendly method for …

miR-181a-regulated pathways in T-cell differentiation and aging

C Kim, Z Ye, CM Weyand, JJ Goronzy - Immunity & Ageing, 2021 - Springer
MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular
processes including cell differentiation and proliferation. Functions of numerous miRNAs …

MicroRNAs as factors in bidirectional crosstalk between mitochondria and the nucleus during cellular senescence

C Giordani, A Silvestrini, A Giuliani, F Olivieri… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are essential organelles that generate most of the chemical energy to power
the cell through ATP production, thus regulating cell homeostasis. Although mitochondria …

Understanding T cell aging to improve anti-viral immunity

H Zhang, CM Weyand, JJ Goronzy… - Current opinion in …, 2021 - Elsevier
T cells are a critical component of the immune system and required for protection against
viral and bacterial infections. However, the capacity of these cells to provide sufficient …

Human Wnt/β-catenin regulates alloimmune signaling during allogeneic transplantation

M Mammadli, R Harris, S Mahmudlu, A Verma, A May… - Cancers, 2021 - mdpi.com
Simple Summary This manuscript showed that Wnt/β-catenin plays a significant role in T cell-
mediated GVHD after allogeneic transplantation. Our functional and genetic data …

Chemotherapy synergizes with cancer vaccines and expands stem-like TCF1+ CD8+ T cells

L Noblecourt, A Wicki, V Pereira-Almeida, J McAuliffe… - bioRxiv, 2023 - biorxiv.org
Therapeutic cancer vaccines, whether based on neoantigens or shared antigens, will likely
be given in the clinic together with the standard of care, which often comprises immune …

TCF-1 in CD4 T cells regulates GVHD severity and persistence

R Harris, M Mammadli, A May, Q Yang, ITH Fung… - bioRxiv, 2021 - biorxiv.org
Graft-versus-host disease (GVHD) is a leading cause of mortality following allogeneic
hematopoietic stem cell transplantation (allo-HSCT). Mature donor T cells in the graft …

Novel candidates for chronic diabetic wound healing

MS Khan, TA Malik - Journal of Pakistan Association of Dermatologists, 2022 - jpad.com.pk
Abstract Diabetic Foot Ulcer (DFU) is a leading cause of amputation in adult population all
over the world. Molecular pathology of delay in wound healing of diabetic foot ulcer patient …