Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-
less condensates, for example, protein aggregates. An unsolved question is why the …

Fluorescence microscopy data describe protein localization patterns at single-cell resolution
and have the potential to reveal whole-proteome functional information with remarkable …

Decline of mitochondrial function is a hallmark of cellular aging. To counteract this process,
some cells inherit mitochondria asymmetrically to rejuvenate daughter cells. The molecular …

Genome instability can drive aging in many organisms. The ribosomal RNA gene (rDNA)
cluster is one of the most unstable regions in the genome and the stability of this region …

The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast
mother cells has been long cited as the primary driver of replicative ageing. ERCs arise …

Automating the extraction of meaningful temporal information from sequences of microscopy
images represents a major challenge to characterize dynamical biological processes. So far …