Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

Telomeres and telomerase play a crucial role in human aging and cancer. Three “drivers” of
human aging can be identified. The developmental program encoded in DNA is the primary …